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The 5 mg vial deliberately reconstitutes to the lowest 2.5 mg/mL concentration, which makes the small starting doses easy to measure but pushes larger doses well past a single barrel

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It shifted the focus: a patients well-being must always come before the interests of science. 1996: The Universal Rulebook (GCP) To ensure a trial in London is as reliable as one in Tokyo, the Good Clinical Practice (GCP) guidelines were established